Relation between HLA antigens and skin cancer in renal transplant recipients in Queensland, Australia
Relation between HLA antigens and skin cancer in renal transplant recipients in Queensland, Australia
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DOI：
10.1111/1523-1747.ep12292086
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发表时间：
1997-05-01
影响因子：
6.5
通讯作者：
Hardie, IR
中科院分区：
文献类型：
--
作者：
Bavinck, JNB;Claas, FHJ;Hardie, IR
在以往研究表明人类白细胞抗原A11与肾移植受者皮肤癌呈负相关、与人类白细胞抗原B27和人类白细胞抗原DR7呈正相关的基础上，我们在昆士兰对1098名受者进行了一项研究，以解决是否可以发现同样的相关性的问题，还研究了人类白细胞抗原错配和人类白细胞抗原纯合性对皮肤癌风险的影响。与先前的研究相比，人类白细胞抗原-A11与皮肤癌的风险增加有关，另一方面，我们证实了人类白细胞抗原-B27与皮肤癌的发生有关，但只有当仅考虑基底细胞癌的发展时，我们证实了人类乳头瘤病毒与人类白细胞抗原DR7的相关性很弱，但在统计学上并不显著，没有观察到人类白细胞抗原错配或纯合子与皮肤癌的发生有关联，环境因素，如不同程度的阳光暴晒和感染人乳头瘤病毒是最有可能参与的因素，我们推测，在居住在荷兰的受者的皮肤癌中，人类乳头瘤病毒诱导的抗原占优势，而在居住在昆士兰的受者的皮肤癌中，由太阳辐射诱导的抗原，即所谓的‘光抗原’，可能更常见。暴露在阳光下也会导致免疫无反应，因此，在澳大利亚过度暴露在阳光下可能会简单地忽略在气候较温和的国家很重要的风险因素。
On the basis of previous studies that showed a negative association between HLA-A11 and skin cancer in renal transplant recipients and a positive association with HLA-B27 and HLA-DR7, we performed a study in Queensland with 1098 recipients to address the question of whether the same associations could be found, The influence of HLA mismatching and HLA homozygosity on the risk of skin cancer was also studied, In contrast to earlier studies, HLA-A11 was associated with an increased risk of skin cancer, On the other hand, we confirmed that the HLA-B27 antigen was associated with the development of skin cancer, but only when the development of basal cell carcinomas alone was considered, and we confirmed that there is a weak but not statistically significant association with HLA-DR7, No association between HLA mismatching or HLA homozygosity and the development of skin cancer was observed, Environmental factors such as different levels of exposure to sunlight and infection with human papillomaviruses are factors that are most likely to be involved, We hypothesize that human papillomavirus-induced antigens prevail in the skin cancers in the recipients living in the Netherlands, whereas antigens induced by solar radiation, the so-called ''photo-antigens,'' may be more common in the skin cancers of the recipients living in Queensland. Exposure to sunlight can also induce immunologic unresponsiveness, and excessive exposure to sunlight in Australia may, therefore, simply override the risk factors that are important in countries with a more temperate climate.