Cytokines of the γ(c) family control CD4+ T cell differentiation and function.
Cytokines of the γ(c) family control CD4+ T cell differentiation and function.
复制标题
DOI：
10.1038/ni.2431
复制
发表时间：
2012-11
影响因子：
30.5
通讯作者：
Paul WE
中科院分区：
文献类型：
--
作者：
Yamane H;Paul WE
初始CD4+ T细胞在识别树突状细胞呈递的外源抗原衍生肽后，经历大量增殖并分化为至少四种不同的辅助T细胞亚群。每个辅助性T细胞亚群表达一组不同的基因，这些基因编码独特的转录因子，以及标志性的细胞因子。激活的CD4+ T细胞、树突状细胞和/或其他细胞类型在分化过程中产生的细胞因子环境是辅助T细胞命运的主要决定因素。本文综述了普通γ链（γc）家族细胞因子在确定初始CD4+ T细胞被激活后所采用的效应辅助T细胞表型以及这些辅助T细胞功能中的作用。
Naive CD4+ T cells undergo massive proliferation and differentiation into at least four distinct helper T cell subsets after recognition of foreign antigen–derived peptides presented by dendritic cells. Each helper T cell subset expresses a distinct set of genes that encode unique transcription factor(s), as well as hallmark cytokines. The cytokine environment created by activated CD4+ T cells, dendritic cells and/or other cell types during the course of differentiation is a major determinant for the helper T cell fate. This Review focuses on the role of cytokines of the common γ-chain (γc) family in the determination of the effector helper T cell phenotype that naive CD4+ T cells adopt after being activated and in the function of these helper T cells.