Quantitative histological studies on the pathogenesis of uremic bone disease.
Quantitative histological studies on the pathogenesis of uremic bone disease.
复制标题
尿毒症骨病发病机制的定量组织学研究。
DOI：
10.1210/jcem-39-1-119
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
N. Maloney
中科院分区：
文献类型：
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作者：
D. Sherrard;D. Baylink;J. Wergedal;N. Maloney
摘要将22例慢性尿毒症患者根据骨组织组织学定量分为3组：1)轻度（10例）；2)骨软化症(6)；3)纤维化(6)。轻度组成形面增加；在骨软化组，矿化延迟发生；在纤维化组，骨髓纤维化、骨形成和再吸收增加。由于轻度组的肾脏疾病持续时间短得多，因此被认为是其他两组的前兆。此外，许多骨骼参数与肾脏疾病持续时间呈正相关。由于肾脏疾病的持续时间在骨软化组和纤维化组是相似的，其中一种似乎不是另一种的中间形式。矿化缺陷局限于骨软化组，但不是由于低钙所致，因为血清钙正常，3组间无差异。轻度组和纤维化组的大多数变化（表面形成增加）…
ABSTRACT Twenty-two patients with chronic uremia were separated into 3 groups on the basis of quantitative bone histology: 1) mild (10 patients); 2) osteomalacic (6); and 3) fibrotic (6). In the mild group there was an increase in forming surface; in the osteomalacic group, a delayed onset of mineralization; in the fibrotic group, increases in marrow fibrosis, bone formation and resorption. Since duration of renal disease was much shorter in the mild group, it was considered a precursor of the other 2 groups. In addition there were positive correlations between a number of bone parameters and duration of renal disease. Since duration of renal disease was similar in the osteomalacic and fibrotic groups, one did not appear to be an intermediate form of the other. The mineralization defect was confined to the osteomalacic group, but was not due to hypocalcemia, since serum calcium was normal and did not differ among the 3 groups. Most of the changes in the mild and fibrotic groups (increases in forming surfa...