Direct Growth of Microspheres on Amorphous Precursor Domains in Polymer-Controlled Crystallization of Indomethacin
Direct Growth of Microspheres on Amorphous Precursor Domains in Polymer-Controlled Crystallization of Indomethacin
复制标题
吲哚美辛聚合物控制结晶中微球在无定形前体结构域上的直接生长
DOI：
10.1021/acs.cgd.5b01522
复制
发表时间：
2016-03-01
影响因子：
3.8
通讯作者：
Liu, Xiang Yang
中科院分区：
文献类型：
--
作者：
Huang, Yu;Jiang, Yuan;Liu, Xiang Yang
Polymer-controlled crystallization is becoming an increasingly important approach to achieve functional materials precipitated from the solution phase. Nevertheless, there exist multiple pathways under the control of yet unpredictable kinetic factors, which significantly hinder the mechanistic understanding. Herein, the mechanistic study of polymer-controlled precipitation of a typical drug compound, indomethacin, was performed. The presence of a nonionic additive poly(vinylpyrrolidone) induces the heterogeneous nucleation of networks of dumbbell-shaped crystalline microspheres on amorphous precursor domains, which is an emerging pathway in polymer-controlled crystallization. This pathway is also verified in the precipitation of l-histidine in the presence of poly(acrylic acid) in the current study. As a comparison, the presence of a cationic polymeric additive, branched polyethylenimine, promotes the formation of aggregates of amorphous nanoparticles and the subsequent crystallization of a spherical-shap...
