Copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds
Copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds
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DOI：
10.1021/jo801322p
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发表时间：
2008-10-03
影响因子：
3.6
通讯作者：
Powell, David A.
中科院分区：
文献类型：
--
作者：
Borduas, Nadine;Powell, David A.
本文报道了铜催化的苄基C-H键与1，3-二羰基化合物的氧化偶联反应。该反应利用廉价的铜催化剂-氧化剂体系，其适合于一系列苄基C-H键与各种1，3-二羰基化合物的偶联。动力学同位素研究支持涉及苄型氢提取的机制。
A copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds is described. The reaction utilizes an inexpensive copper catalyst - oxidant system that is suitable for the coupling of a range of benzylic C-H bonds with various 1,3-dicarbonyl compounds. Kinetic isotope studies support a mechanism involving a benzylic hydrogen abstraction.