From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate
From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate
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DOI：
10.1126/scisignal.2002943
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发表时间：
2012-03-13
影响因子：
7.3
通讯作者：
Finkel, Toren
中科院分区：
文献类型：
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作者：
Finkel, Toren
人们越来越认识到，氧化剂如过氧化氢（H2O2）和气体如一氧化氮（NO）和硫化氢（H2S）可以作为各种信号传导途径的调节剂。这种信号传导大部分通过靶蛋白中特定的关键半胱氨酸残基的修饰发生。这种小的可扩散分子（H2O2、NO、H2S）如何能够实现所需的特异性尚不完全清楚。现在，新的发现为这些和相关问题提供了相当多的见解。
There is a growing appreciation that oxidants such as hydrogen peroxide (H2O2) and gasses such as nitric oxide (NO) and hydrogen sulfide (H2S) can act as modulators of various signaling pathways. Much of this signaling occurs through the modifications of specific, critical cysteine residues in target proteins. How such small diffusible molecules (H2O2, NO, H2S) can achieve the required specificity is incompletely understood. Now, new findings provide considerable insight into these and related questions.