Pseudorabies virus infection in Oklahoma hunting dogs
Pseudorabies virus infection in Oklahoma hunting dogs
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DOI：
10.1177/1040638711416628
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发表时间：
2011-09-01
影响因子：
1.5
通讯作者：
Maes, Roger K.
中科院分区：
文献类型：
--
作者：
Cramer, Sarah D.;Campbell, Gregory A.;Maes, Roger K.
伪狂犬病是由猪疱疹病毒1型引起的，它是α疱疹病毒亚科的一个成员。虽然猪是伪狂犬病病毒（PRV）的天然宿主，但该病毒具有广泛的宿主范围，并可在许多物种中引起致命性脑炎。美国在2004年从国内养猪场根除了PRV病毒后获得了无PRV状态，但该病毒仍然存在于野生猪群中。目前的报告描述了3只用于狩猎野猪的犬的PRV感染。犬出现临床体征，包括面部瘙痒伴面部擦伤、呼吸困难、呕吐、腹泻、共济失调、肌肉僵硬和死亡。2例被人道处死，1例在临床体征发生后约48小时内死亡。显著的组织学改变包括嗜中性三叉神经节神经炎伴神经元吞噬和可疑的核内包涵体。从其中2只犬的新鲜组织中分离出伪狂犬病病毒，并在第3只犬中进行免疫组织化学检测。根据现有的GenBank序列，病毒测序和同源性分析显示，该病毒可能是一种与先前在伊利诺伊州鉴定的一组PRV毒株密切相关的野外毒株。虽然在美国已从家猪中根除，但PRV仍存在于野生猪群中，因此应继续被视为犬和其他具有相容临床病史和体征的家畜的可能致病原因。继续监测是必要的，以防止PRV重新引入家猪。
Pseudorabies is caused by Suid herpesvirus 1, a member of the Alphaherpesvirinae subfamily. Although pigs are the natural host of Pseudorabies virus (PRV), the virus has a broad host range and may cause fatal encephalitis in many species. The United States obtained PRV-free status in 2004 after the virus was eradicated from domestic swineherds, but the virus is still present in feral swine populations. The current report describes PRV infection in 3 dogs that were used to hunt feral swine. The dogs developed clinical signs including facial pruritus with facial abrasions, dyspnea, vomiting, diarrhea, ataxia, muscle stiffness, and death. Two were euthanized, and 1 died within approximately 48 hr after onset of clinical signs. The salient histologic changes consisted of neutrophilic trigeminal ganglioneuritis with neuronophagia and equivocal intranuclear inclusion bodies. Pseudorabies virus was isolated from fresh tissues from 2 of the dogs, and immunohistochemistry detected the virus in the third dog. Virus sequencing and phylogeny, based upon available GenBank sequences, revealed that the virus was likely a field strain that was closely related to a cluster of PRV strains previously identified in Illinois. Though eradicated from domestic swine in the United States, PRV is present in populations of feral swine, and should therefore continue to be considered a possible cause of disease in dogs and other domestic animals with compatible clinical history and signs. Continued surveillance is necessary to prevent reintroduction of PRV into domestic swine.