Intraspecific genetic variation for anesthesia success in a New Zealand freshwater snail

Intraspecific genetic variation for anesthesia success in a New Zealand freshwater snail
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新西兰淡水蜗牛麻醉成功的种内遗传变异

DOI:
10.1007/s10709-020-00110-6
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发表时间:
2021
期刊:
影响因子:
1.5
通讯作者:
Neiman, Maurine
Neiman, Maurine
中科院分区:
生物学4区
文献类型:
--
作者:
Song, Qiudong;Magnuson, Richard;Jalinsky, Joseph;Roseman, Marissa;Neiman, Maurine

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种内遗传变异可以驱动表型变异,甚至在非常密切相关的个体之间。在这里,我们证明了蜗牛之间的遗传差异是一个重要的淡水蜗牛模型系统,Potamopyrgus antipodarum的薄荷醇麻醉成功的广泛变化的主要贡献者。麻醉被用于实验和外科手术中麻醉生物体,并人道地减轻疼痛。这是第一个例子,我们知道的作用,在软体动物麻醉成功的遗传变异。这些发现强调了这样一个事实,即仅使用一种菌株或谱系进行许多实验将无法提供表型变异的全貌,证明了在各种遗传背景下优化生物医学相关技术和方案的重要性,阐明了先前记录的软体动物麻醉挑战的潜在机制,并为P中强大和人性化的操纵实验奠定了基础。对跖点。
Intraspecific genetic variation can drive phenotypic variation even across very closely related individuals. Here, we demonstrate that genetic differences between snails are a major contributor to wide variation in menthol anesthesia success in an important freshwater snail model system,Potamopyrgus antipodarum. Anesthesia is used to immobilize organisms for experiments and surgical procedures and to humanely mitigate pain. This is the first example of which we are aware of a role for genetic variation in anesthesia success in a mollusk. These findings highlight the fact that using only one strain or lineage for many experiments will not provide a full picture of phenotypic variation, demonstrate the importance of optimizing biomedically relevant techniques and protocols across a variety of genetic backgrounds, illuminate a potential mechanism underlying previously documented challenges in molluscan anesthesia, and set the stage for powerful and humane manipulative experiments inP. antipodarum.
DOI: 10.1037/016612
发表时间: 1978
期刊: Aquaculture
影响因子: 4.5
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DOI: --
发表时间: 2007
期刊:
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作者:
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