Near-infrared spectroscopy of orbitofrontal cortex during odorant stimulation
Near-infrared spectroscopy of orbitofrontal cortex during odorant stimulation
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DOI：
10.2500/ajra.2011.25.3634
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发表时间：
2011-05-01
影响因子：
2.6
通讯作者：
Nibu, Ken-ichi
中科院分区：
文献类型：
--
作者：
Kokan, Norio;Sakai, Nobuyuki;Nibu, Ken-ichi
背景：对于嗅觉，一些研究报道了气味刺激时眶前皮质(OFC)近红外光谱(NIRS)信号的变化。然而，人类OFC在嗅觉认知中的作用却知之甚少。本研究旨在更好地了解OFC在嗅觉中的作用。方法：用近红外光谱技术测量OFC对苯乙醇或柠檬醛的血流动力学反应。实验结束后，参与者被要求描述气味的特征，并对气味强度和享乐价进行评级。结果：对所有参与者数据的统计分析显示，在实验过程中，左侧OFC中的总血红蛋白浓度发生了显著变化(p=0.04)。成功识别气味刺激的受试者右侧OFC的总血红蛋白信号显著增加(p=0.0008)。结论：近红外光谱结合问卷是研究嗅觉功能神经解剖学的有用方法。(Am J Rhinol AllEnergy 25,1631652011年；DOI：10.2500/ajra.2011.25.3634)
Background: For olfaction, several studies have reported near-infrared spectroscopy (NIRS) signal changes in the orbitofrontal cortex (OFC) during odor stimulation. However, the roles of human OFC in olfactory cognition are less well understood. This study was designed to better understand the roles of OFC for olfaction.Methods: Hemodynamic responses for phenyl ethyl alcohol or citral in the OFCs were measured with NIRS. After the experiment, participants were asked to describe the characteristics of the odor and to rate odor intensity and hedonic valence.Results: Statistical analysis of all participants' data showed significant changes in the concentration of total hemoglobin in the left OFC during the trial (p = 0.04). The total hemoglobin signal increased significantly in the right OFC (p = 0.0008) of the participants who successfully identified the odorant stimulus.Conclusion: Our findings showed that NIRS combined with a questionnaire is a useful method for studying the functional neuroanatomy of OFC in terms of olfaction. (Am J Rhinol Allergy 25, 163-165, 2011; doi: 10.2500/ajra.2011.25.3634)