Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors?
Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors?
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DOI：
10.1016/j.jjcc.2016.02.003
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发表时间：
2016-09-01
影响因子：
2.5
通讯作者：
Komuro, Issei
中科院分区：
文献类型：
--
作者：
Lee, Seitetsu L.;Daimon, Masao;Komuro, Issei
背景：左房容积（LAV）升高预示着心血管事件的高发生率，被广泛认为是左室舒张功能障碍（DD）的主要替代指标。虽然左室增大的病理生理可能是多因素的，但很少有研究在没有瓣膜疾病或左室收缩功能障碍的情况下全面检查导致左室增大的临床因素。因此，我们研究了LAV与包括dd在内的一些临床和超声心动图参数之间的关系。方法：我们回顾性地招募了557名无明显瓣膜疾病或左室收缩功能障碍的临床体检对象。我们以In LAV指数为因变量，并以以下自变量：性别、年龄、吸烟状况、饮酒习惯、高血压、糖尿病、体重指数（BMI）、左室射血分数、DD、左室质量指数、血红蛋白、血清肌酐、血清总胆固醇、血清尿酸、血清钠和血清铁进行单变量和多变量线性回归。结果：在多变量分析中，与正常舒张功能相比，LAV指数与BMI、低血红蛋白、中重度DD独立相关（p < 0.001），但与轻度DD无关（p = 0.70）。结论：LA增大与中度和重度DD独立相关，但与轻度DD无关。此外，肥胖和低血红蛋白与LAV相关，独立于DD。(C) 2016日本心脏病学院。Elsevier Ltd.出版。版权所有。
Background: Increased left atrial volume (LAV) predicts a higher incidence of cardiovascular events and is widely recognized as a major surrogate marker of left ventricular (LV) diastolic dysfunction (DD). Although the pathophysiology of LA enlargement is probably multifactorial, few studies have examined comprehensively the clinical factors that lead to LA enlargement in the absence of valvular disease or LV systolic dysfunction. Therefore, we investigated associations between LAV and several clinical and echocardiographic parameters including DD.Methods: We enrolled 557 subjects without significant valve disease or LV systolic dysfunction from the health check-up clinic retrospectively. We performed univariable and multivariable linear regression using In LAV index as the dependent variable and the following independent variables: gender, age, smoking status, drinking habit, hypertension, diabetes, body mass index (BMI), LV ejection fraction, DD, LV mass index, hemoglobin, serum creatinine, serum total cholesterol, serum uric acid, serum sodium, and serum iron.Results: In multivariable analysis, LAV index was independently associated with BMI, lower hemoglobin, and moderate and severe DD compared with normal diastolic function (p < 0.001), but not with mild DD (p = 0.70).Conclusions: LA enlargement was independently associated with moderate and severe DD, but not with mild DD. Furthermore, obesity and lower hemoglobin were associated with LAV independently of DD. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.