The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.
The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.
复制标题
潜在痴呆表型 δ 与阿尔茨海默氏病的脑脊液生物标志物相关，可预测轻度认知障碍受试者转化为痴呆。
DOI：
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
M. Wagner
中科院分区：
文献类型：
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作者：
Alexander Koppara;S. Wolfsgruber;L. Kleineidam;K. Schmidtke;L. Frölich;A. Kurz;S. Schulz;H. Hampel;I. Heuser;O. Peters;F. Reischies;H. Jahn;C. Luckhaus;M. Hüll;H. Gertz;J. Schröder;J. Pantel;O. Rienhoff;E. Rüther;F. Henn;J. Wiltfang;W. Maier;F. Jessen;J. Kornhuber;M. Wagner
背景
最近提出的潜在变量δ是一种新的痴呆病例发现工具。它建立在认知和功能数据的结构方程建模框架中，并构成了阿尔茨海默病(AD)研究和临床试验的一种新的内表型。
客观化
目的：探讨δ与AD生物标志物之间的关系，并与已建立的轻度认知障碍患者向痴呆转化的量表进行比较，以预测δ。
方法
使用来自多中心记忆临床研究的数据，我们检查了潜在变量δ的外部联系，并将δ与公认的认知和功能量表以及认知-功能综合评分进行了比较。为此，以脑脊液(CSF)生物标志物和痴呆症转化为因变量进行Logistic回归分析。对这些模型进行了显著差异测试。
结果
在轻度认知障碍患者中，δ基于广泛的认知量表(包括ADAS-COG、简易智力状态检查和CERAD神经心理测验)预测脑脊液Aβ42/tau比值异常，表明AD(n = 340，AUC = 0.78，p <； 0.001)，并预测在1-3年内发生痴呆(n = 525，AUC = 0.84，p <； 0.001)。这些关联性通常比任何其他量表或认知功能复合体都要强。基于简化测试电池的δ同系物产生的效果略低。
结论
这些发现支持将δ解释为捕捉轻度认知障碍和痴呆症患者认知和功能障碍的疾病相关“本质”的结构，并暗示δ可能成为痴呆症研究的分析工具。
BACKGROUND
The recently proposed latent variable δ is a new tool for dementia case finding. It is built in a structural equation modeling framework of cognitive and functional data and constitutes a novel endophenotype for Alzheimer's disease (AD) research and clinical trials.
OBJECTIVE
To investigate the association of δ with AD biomarkers and to compare the prediction of δ with established scales for conversion to dementia in patients with mild cognitive impairment (MCI).
METHODS
Using data from a multicenter memory clinic study, we examined the external associations of the latent variable δ and compared δ with well-established cognitive and functional scales and cognitive-functional composite scores. For that purpose, logistic regressions with cerebrospinal fluid (CSF) biomarkers and conversion to dementia as dependent variables were performed with the investigated scores. The models were tested for significant differences.
RESULTS
In patients with MCI, δ based on a broad range of cognitive scales (including the ADAS-cog, the MMSE, and the CERAD neuropsychological battery) predicted an abnormal CSF Aβ42/tau ratio indicative of AD (n = 340, AUC = 0.78, p < 0.001), and predicted incident dementia within 1-3 years of follow-up (n = 525, AUC = 0.84, p < 0.001). These associations were generally stronger than for any other scale or cognitive-functional composite examined. Homologs of δ based on reduced test batteries yielded somewhat lower effects.
CONCLUSION
These findings support the interpretation of δ as a construct capturing the disease-related "essence" of cognitive and functional impairments in patients with MCI and dementia, and suggest that δ might become an analytical tool for dementia research.
DOI：
10.1176/ajp.141.11.1356
发表时间：
1984-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
W. Rosen;R. Mohs;K. Davis
通讯作者：
W. Rosen;R. Mohs;K. Davis
影响因子：
22.4
作者：
BENTLER, PM
通讯作者：
BENTLER, PM