MECHANISM OF PANCREATIC POLYPEPTIDE RELEASE IN MAN
MECHANISM OF PANCREATIC POLYPEPTIDE RELEASE IN MAN
复制标题
胰腺多肽在人体内的释放机制
DOI：
10.1016/s0140-6736(77)91762-7
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R.G Faber
中科院分区：
文献类型：
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作者：
T. E. Adrian;H. Besterman;T. Cooke;S. R. Bloom;A. Barnes;R. Russell;R.G Faber
胰多肽（P. P.）是一种从胰腺中分离出来的强效激素肽。它在人体生理学和病理学中的作用尚未确定。标准医院午餐后，10名健康对照、11名十二指肠溃疡患者和6名迷走神经切除术后患者的血浆PP浓度显示出快速且相同的升高，但在4名完全胰腺切除术受试者中仍未检测到。相反，血浆-P. P.不受静脉注射葡萄糖、氨基酸或脂肪的影响。然而，在静脉输注蛙皮素（一种胆囊收缩素类似物）时，P. P升高了近5倍，而在静脉注射Boots分泌素后，P. P的升高幅度更大。在19例胃溃疡患者中，胰岛素低血糖导致血浆P. P迅速升高，但在研究的17例迷走神经干切断术后的患者中，没有一例发生这种情况。因此，P. P.是通过口服而不是静脉营养释放的，并假定存在肠-P. P.轴。该轴的一个组成部分可能是迷走神经支配，但迷走神经切断术后观察到的正常餐后升高表明其他控制机制，如肠激素，更重要。
Pancreatic polypeptide (P.P.) is a potent hormonal peptide which has been isolated from the pancreas. Its role in human physiology and pathology is not yet established. After a standard hospital lunch the plasma concentration of P.P. showed a rapid and identical rise in 10 healthy controls, 11 duodenal-ulcer patients, and 6 post-vagotomy patients but remained undetectable in 4 totally pancreatectomised subjects. In contrast plasma-P.P. was unaffected by intravenous administration of glucose, aminoacids, or fat. However, during intravenous infusion of cærulein, a cholecystokinin analogue, P.P. rose by nearly five-fold, and an even greater rise was seen after intravenous injection of Boots secretin. In 19 duodenal-ulcer patients insulin hypoglycæmia produced a rapid rise in plasma-P.P. but this did not occur in any of the 17 patients studied after a truncal vagotomy. Thus P.P. is released by oral but not intravenous nutriments and the existence of an entero-P.P. axis is postulated. One component of this axis may be the vagal innervation but the normal postprandial rise seen after vagotomy suggests that other control mechanisms, such as the intestinal hormones, are more important.