Familial aggregation of type 2 diabetes and chronic hypertension in women with gestational diabetes mellitus.
Familial aggregation of type 2 diabetes and chronic hypertension in women with gestational diabetes mellitus.
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发表时间：
2003-12
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通讯作者：
Michelle A Williams;C. Qiu;J. Dempsey;D. Luthy
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作者：
Michelle A Williams;C. Qiu;J. Dempsey;D. Luthy
目的通过病例对照研究，评估父母有2型糖尿病和/或慢性高血压病史的妇女发生妊娠期糖尿病（GDM）的风险增加程度。研究设计参与者（133例GDM病例和373例对照）提供了这两种疾病的一级家族史和其他协变量的信息。Logistic回归程序用于推导比值比和95%置信区间，并根据母亲年龄、种族/民族和孕前肥胖调整混杂因素。结果与父母无糖尿病史的妇女相比，母亲仅患糖尿病（比值比= 2.0）、父亲仅患糖尿病（比值比= 2.3）或母亲和父亲均患糖尿病（比值比= 3.8）的妇女发生GDM的风险显著增加。父母有糖尿病和高血压病史的女性的优势比为2.6（95%置信区间，1.3-5.3）。有糖尿病兄弟姐妹的妇女患GDM的风险增加8.4倍（95%置信区间，2.1-33.4）。慢性高血压一级家族史是GDM风险的预测因素，但仅当高血压与糖尿病诊断相关时。结论：我们的研究结果与糖尿病家族史（单独或与高血压相关）反映遗传和行为因素的论点一致，女性可能倾向于增加GDM的风险。
OBJECTIVE To perform a case-control study to assess the extent to which women with a positive parental history of type 2 diabetes and/or chronic hypertension experienced an increased risk of developing gestational diabetes mellitus (GDM). STUDY DESIGN Participants (133 GDM cases and 373 controls) provided information on first-degree family history of the 2 conditions and other covariates of interest in interviews. Logistic regression procedures were used to derive odds ratios and 95% confidence intervals adjusted for confounding by maternal age, race/ethnicity and prepregnancy adiposity. RESULTS As compared with women with no parental history of diabetes, women with a maternal-only (odds ratio = 2.0), paternal-only (odds ratio = 2.3) or both maternal and paternal history of diabetes (odds ratio = 3.8) experienced a statistically significant increased risk of GDM. The odds ratio for women with a positive parental history of diabetes and hypertension was 2.6 (95% confidence interval, 1.3-5.3). Women with a diabetic sibling had an 8.4-fold increased risk of GDM (95% confidence interval, 2.1-33.4). First-degree family history of chronic hypertension was predictive of GDM risk but only when hypertension was associated with a diagnosis of diabetes. CONCLUSION Our results are consistent with the thesis that family history of diabetes (alone or when associated with hypertension) reflects genetic and behavioral factors whereby women may be predisposed to an increased GDM risk.