Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging.
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging.
复制标题
零星大脑小血管疾病的机制：神经影像学的见解。
DOI：
10.1016/s1474-4422(13)70060-7
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Dichgans M
中科院分区：
文献类型：
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作者：
Wardlaw JM;Smith C;Dichgans M
术语“脑小血管疾病”(SVD)描述了一系列的神经影像、病理和相关的临床特征。后者的范围从无到离散的局灶性神经症状(中风)，到潜伏的全球神经功能障碍和痴呆症。公共卫生负担是相当大的。发病机制在很大程度上还不清楚。虽然与血管危险因素有关，并且通常被认为是由内在的脑小动脉闭塞疾病引起的，但导致小动脉疾病的病理过程，这些过程如何导致脑部疾病，SVD病变如何导致神经或认知症状，以及与危险因素的关系，一直是人们猜测的主题。病理学通常反映终末期疾病，使最早阶段的确定变得困难。神经成像提供了相当大的洞察力：小血管本身并不容易看到，但它们故障对大脑的影响可以通过详细的大脑成像来追踪。我们回顾了关于最可能的机制的越来越多的证据。
The term “cerebral small vessel disease” (SVD) describes a range of neuroimaging, pathological and associated clinical features. The latter range from none, to discrete focal neurological symptoms (stroke), to insidious global neurological dysfunction and dementia. The public health burden is considerable. The pathogenesis is largely unknown. Although associated with vascular risk factors, and generally considered to result from an intrinsic cerebral arteriolar occlusive disease, the pathological processes leading to the arteriolar disease, how these result in brain disease, how SVD lesions contribute to neurological or cognitive symptoms and the relationship to risk factors, have been the subject of much speculation. Pathology often reflects end-stage disease making determination of the earliest stages difficult. Neuroimaging provides considerable insights: the small vessels are not easily seen themselves, but the effects of their malfunction on the brain can be tracked on detailed brain imaging. We review the growing evidence for the most likely mechanisms.