RAPID CORRECTION OF SEVERE HYPONATREMIA WITH INTRAVENOUS HYPERTONIC SALINE SOLUTION
RAPID CORRECTION OF SEVERE HYPONATREMIA WITH INTRAVENOUS HYPERTONIC SALINE SOLUTION
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DOI：
10.1016/0002-9343(82)90575-7
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发表时间：
1982-01-01
影响因子：
5.9
通讯作者：
FROMMER, JP
中科院分区：
文献类型：
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作者：
AYUS, JC;OLIVERO, JJ;FROMMER, JP
严重低钠血症伴低渗血症具有高发病率和死亡率，并构成危及生命的紧急情况。重度低钠血症7例（血清钠浓度99.7±）。3.0 meq/l)(平均值+-。扫描电镜（SEM）[平均SE])报告低渗(212 .+-。8 mmol /kg水)，并伴有严重的神经系统并发症。血钠浓度校正为13.3 +-。2.2 h至轻度低钠血症水平(血清钠浓度128.3 .+-。1.6毫克当量/ l)。血清钠浓度校正率为2.4±±。0.5 meq/l / h。这是通过静脉注射3%高渗生理盐水(687 .+-。43 meq NaCl)和呋塞米，或根据需要进行血液透析。治疗后无并发症发生，全部康复，无神经系统后遗症。早期诊断和快速纠正血清钠浓度似乎可以显著降低严重低钠血症的发病率和死亡率。
Severe hyponatremia with hypoosmolality carries a high morbidity and mortality and constitues a life-threatening emergency. Seven cases of severe hyponatremia (serum Na concentration 99.7 .+-. 3.0 meq/l) (mean .+-. SEM [SE of mean]) were reported with hypoosmolality (212 .+-. 8 mOsm[milliosmole]/kg water) that was presented with severe neurologic complications. Serum Na concentration was corrected in 13.3 .+-. 2.2 h to mildly hyponatremic levels (serum Na concentration 128.3 .+-. 1.6 meq/l). The rate of correction of serum Na concentration was 2.4 .+-. 0.5 meq/l per h. This was achieved by the i.v. administration of 3% hypertonic saline solution (687 .+-. 43 meq NaCl) and furosemide, or by hemodialysis where indicated. No complications occurred from treatment and all of the patients recovered without neurologic sequelae. Early diagnosis and rapid correction of serum Na concentration appear to reduce the significant morbidity and mortality of severe hyponatremia.