The three R's of lung health and disease: repair, remodeling, and regeneration
The three R's of lung health and disease: repair, remodeling, and regeneration
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DOI：
10.1172/jci45961
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发表时间：
2011-06-01
影响因子：
15.9
通讯作者：
Morrisey, Edward E.
中科院分区：
文献类型：
--
作者：
Beers, Michael F.;Morrisey, Edward E.
所有的组织和器官都可以根据它们在成人体内平衡期间和损伤后的修复和再生能力进行分类。一些表现出高速率的恒定细胞更新，而其他的，如肺，在正常的成人稳态期间仅表现出低水平的细胞再生，但在损伤后具有快速再生新细胞的能力。肺再生可能涉及祖细胞的活化以及通过剩余未受损细胞的增殖的细胞替代。控制这一过程的途径和因素及其在疾病中的作用现在才被探索。在这篇综述中，我们将讨论肺发育所需的途径与肺如何应对损伤和疾病之间的联系，特别强调最近的研究描述了上皮细胞在修复和再生中的作用。
All tissues and organs can be classified according to their ability to repair and regenerate during adult homeostasis and after injury. Some exhibit a high rate of constant cell turnover, while others, such as the lung, exhibit only low-level cell regeneration during normal adult homeostasis but have the ability to rapidly regenerate new cells after injury. Lung regeneration likely involves both activation of progenitor cells as well as cell replacement through proliferation of remaining undamaged cells. The pathways and factors that control this process and its role in disease are only now being explored. In this Review, we will discuss the connection between pathways required for lung development and how the lung responds to injury and disease, with a particular emphasis on recent studies describing the role for the epithelium in repair and regeneration.