A CONTROLLED TRIAL OF INTRAVAGINAL ESTRIOL IN POSTMENOPAUSAL WOMEN WITH RECURRENT URINARY-TRACT INFECTIONS
A CONTROLLED TRIAL OF INTRAVAGINAL ESTRIOL IN POSTMENOPAUSAL WOMEN WITH RECURRENT URINARY-TRACT INFECTIONS
复制标题
DOI：
10.1056/nejm199309093291102
复制
发表时间：
1993-09-09
影响因子：
158.5
通讯作者：
STAMM, WE
中科院分区：
文献类型：
--
作者：
RAZ, R;STAMM, WE
背景资料。对许多绝经后妇女来说，反复的尿路感染是一个问题。雌激素替代疗法可修复萎缩的粘膜，降低阴道pH值，并可预防尿路感染。我们招募了93名有反复尿路感染史的绝经后妇女参加了一项随机、双盲、安慰剂对照的阴道内应用雌三醇乳膏的试验。中段尿培养在登记时、每月、连续8个月、以及每当出现尿路症状时进行。在入院时、1个月和8个月后进行阴道培养和酸碱度测量。这些妇女被分配接受雌三醇(n=50)或安慰剂(n=43)，均经阴道给药；36名和24名分别完成了8个月的随访。与安慰剂组相比，服用雌三醇组的尿路感染发生率显著降低(0.5次/病人年，5.9次/病人年，P
Background. Recurrent urinary tract infections are a problem for many postmenopausal women. Estrogen replacement restores atrophic mucosa, lowers vaginal pH, and may prevent urinary tract infections.Methods. We enrolled 93 postmenopausal women with a history of recurrent urinary tract infections in a randomized, double-blind, placebo-controlled trial of a topically applied intravaginal estriol cream. Midstream urine cultures were obtained at enrollment, monthly for eight months, and whenever urinary symptoms occurred. Vaginal cultures and pH measurements were obtained at entry and after one and eight months. The women were assigned to receive either estriol (n = 50) or placebo (n = 43), both administered intravaginally; 36 and 24, respectively, completed the eight months of follow-up.Results. The incidence of urinary tract infection in the group given estriol was significantly reduced as compared with that in the group given placebo (0.5 vs. 5.9 episodes per patient-year, P