Out-of-hospital medication storage temperatures: a review of the literature and directions for the future.
Out-of-hospital medication storage temperatures: a review of the literature and directions for the future.
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DOI：
10.1016/j.prehos.2003.12.017
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发表时间：
2004-04-01
期刊：
影响因子：
--
通讯作者：
Fullagar, Christopher J
中科院分区：
文献类型：
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作者：
Brown, Lawrence H;Krumperman, Kurt;Fullagar, Christopher J
美国药典（USP）国家处方集规定了药物的包装，储存和分销。大多数紧急医疗服务（EMS）常用的药物都是在“受控室温”下储存的。“美国药典对受控室温的定义是多方面的和复杂的，不能简单地描述为一个可接受的温度范围，甚至是一个平均温度。众所周知，医院外的环境是不受控制的，其中一个不受控制的方面就是温度。本报告回顾并总结了过去15年发表的与院外用药温度暴露相关的研究。虽然有证据表明EMS药物储存与USP对受控室温的定义不一致，但EMS药物储存对药物稳定性和效力的影响仍不清楚。需要进一步研究，以确定EMS药物储存问题的真实程度，并制定和验证适当的解决方案。
The United States Pharmacopeia (USP) National Formulary prescribes the packaging, storage, and distribution of medications. Most of the medications commonly used by emergency medical services (EMS) are intended for storage at "controlled room temperature." The USP definition of controlled room temperature is multifaceted and complex, and cannot be easily described as a simple range of acceptable temperatures, or even as an average temperature. The out-of-hospital environment is notoriously uncontrolled, and one of the uncontrolled aspects of that environment is temperature. This report reviews and summarizes the past 15 years of published research relating to out-of-hospital medication temperature exposures. Although the evidence is clear that EMS medication storage is not consistent with the USP definition of controlled room temperature, the impact of EMS medication storage on medication stability and potency remains unclear. Further research is needed to determine the true extent of the EMS medication storage problem, and to develop and validate appropriate solutions.