A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.
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DOI：
10.1146/annurev-physiol-021113-170252
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发表时间：
2014
影响因子：
18.2
通讯作者：
Saito M
中科院分区：
文献类型：
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作者：
Kajimura S;Saito M
棕色脂肪组织（BAT）专门以热的形式耗散化学能，以抵御寒冷和过度进食。在过去的几年里，人们对BAT生物学领域的兴趣激增，因为BAT在对抗肥胖和肥胖相关疾病（包括胰岛素抵抗）方面的治疗潜力。已经取得了很大的进展，特别是在成年人的BAT生理学，棕色脂肪细胞命运的发育谱系和BAT产热的激素控制等领域。随着我们进入棕色脂肪生物学的新时代，下一个挑战将是开发激活成年人BAT产热的策略，以增加全身能量消耗。本文回顾了这一领域的最新进展，并讨论了新出现的问题。
Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control of BAT thermogenesis. As we enter into a new era of brown fat biology, the next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure. This article reviews the recent major advances in this field and discusses emerging questions.
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影响因子：
64.5
作者：
Fedorenko A;Lishko PV;Kirichok Y
通讯作者：
Kirichok Y
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
2.7
作者：
Atit, Radhika;Sgaier, Sema K.;Conlon, Ronald A.
通讯作者：
Conlon, Ronald A.
影响因子：
4.6
作者：
Coulter, AA;Bearden, CM;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
64.8
作者：
通讯作者：
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