Vaccines and immunotherapeutics for the treatment of malignant disease.

Vaccines and immunotherapeutics for the treatment of malignant disease.
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DOI:
10.1155/2010/697158
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发表时间:
2010
影响因子:
--
通讯作者:
Kennedy RC
Kennedy RC
中科院分区:
其他
文献类型:
--
作者:
Aldrich JF;Lowe DB;Shearer MH;Winn RE;Jumper CA;Kennedy RC

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利用免疫系统治疗恶性疾病是生物医学研究的一个活跃领域。免疫反应的特异性和建立长期肿瘤免疫的潜力迫使研究人员继续研究癌症的免疫治疗方法。已经出现了许多用于治疗恶性疾病的免疫治疗策略,包括各种疫苗接种方案、细胞因子疗法、过继细胞疗法和单克隆抗体疗法。本文描述了每一种策略,并讨论了一些相关的成功和局限性。重点放在技术的整合上,以促进消除癌症的最佳方案。
The employment of the immune system to treat malignant disease represents an active area of biomedical research. The specificity of the immune response and potential for establishing long-term tumor immunity compels researchers to continue investigations into immunotherapeutic approaches for cancer. A number of immunotherapeutic strategies have arisen for the treatment of malignant disease, including various vaccination schemes, cytokine therapy, adoptive cellular therapy, and monoclonal antibody therapy. This paper describes each of these strategies and discusses some of the associated successes and limitations. Emphasis is placed on the integration of techniques to promote optimal scenarios for eliminating cancer.
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发表时间: 2006-05-11
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