The HRASLS (PLA/AT) subfamily of enzymes.
The HRASLS (PLA/AT) subfamily of enzymes.
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DOI：
10.1186/s12929-015-0210-7
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发表时间：
2015-10-26
影响因子：
11
通讯作者：
Duncan RE
中科院分区：
文献类型：
--
作者：
Mardian EB;Bradley RM;Duncan RE
H-RAS样抑制子(HRASLS)亚家族由5种酶(1-5)和3种(1、3、5)组成，它们与卵磷脂有同源性：视黄醇酰基转移酶(LRAT)。所有HRASLS家族成员在体外都具有磷脂代谢能力，包括磷脂酶A1/2(PLA1/2)活性和用于甘油磷脂酰链重塑的O-酰基转移酶活性，以及用于产生N-酰基磷脂酰乙醇胺的N-酰基转移酶活性。HRASLS酶的体内生物学活性尚未得到充分研究。到目前为止的研究表明，这一亚家族参与了广泛的生物学过程，因此，这五种酶在不同的研究领域经历了广泛的重新发现和重新命名。本文简要介绍了每种HRASLS酶的发现及其在癌症中的作用，并讨论了每种酶的生化功能以及生物学作用(如果已知)。强调了目前认识上的差距，并讨论了对未来研究方向的建议。
The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans and three (1, 3, and 5) in mice and rats that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRASLS family members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains, as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines. The in vivo biological activities of the HRASLS enzymes have not yet been fully investigated. Research to date indicates involvement of this subfamily in a wide array of biological processes and, as a consequence, these five enzymes have undergone extensive rediscovery and renaming within different fields of research. This review briefly describes the discovery of each of the HRASLS enzymes and their role in cancer, and discusses the biochemical function of each enzyme, as well as the biological role, if known. Gaps in current understanding are highlighted and suggestions for future research directions are discussed.