Self-induced structural switches in RNA
Self-induced structural switches in RNA
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DOI：
10.1016/s0300-9084(02)01448-7
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发表时间：
2002-09-01
期刊：
影响因子：
3.9
通讯作者：
Pleij, CWA
中科院分区：
文献类型：
--
作者：
Nagel, JHA;Pleij, CWA
许多具有生物活性的rna在其二级结构中显示出开关，这伴随着其功能的变化。二级结构的这种变化通常需要反式作用因子，例如RNA伴侣。然而，一些具有生物活性的rna不需要反式作用因子来进行这种结构开关，因此这里将其称为“自诱导开关”。这些自激结构开关有几个共同的特点。它们都是从亚稳态结构开始的，这种结构可以维持一段时间，允许或阻止RNA的特定功能。此后，一个结构元件变得可用，例如在转录过程中，触发快速过渡到稳定的构象，这再次伴随着功能的获得或丧失。这类开关的另一个共同元素是参与分支迁移或链位移反应，这足以降低反应的能量势垒，从而允许快速再折叠。在这里，我们回顾了在RNA二级结构中提出的一些自诱导开关。提出了这种开关的一般模型，显示了它在功能活性rna生物学中的重要性。(C) 2002年法国生物化学和生物分子学会/爱思唯尔SAS科学和医学版。版权所有。
Many biologically active RNAs show a switch in their secondary structure, which is accompanied by changes in their function. Such changes in secondary structure often require trans-acting factors, e.g. RNA chaperones. However, several biologically active RNAs do not require trans-acting factors for this structural switch, which is therefore indicated here as a "self-induced switch". These self-induced structural switches have several characteristics in common. They all start from a metastable structure, which is maintained for some time allowing or blocking a particular function of the RNA. Hereafter, a structural element becomes available, e.g. during transcription, triggering a rapid transition into a stable conformation, which again is accompanied by either a gain or loss of function. A further common element of this type of switches is the involvement of a branch migration or strand displacement reaction, which lowers the energy barrier of the reaction sufficiently to allow rapid refolding. Here, we review a number of these self-induced switches in RNA secondary structure as proposed for several systems. A general model for this type of switches is presented, showing its importance in the biology of functionally active RNAs. (C) 2002 Societe francaise de biochimie et biologie moleculaire/Editions scientitiques et medicales Elsevier SAS. All rights reserved.