The nature of robustness in development
The nature of robustness in development
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DOI：
10.1002/bies.10093
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发表时间：
2002-06-01
期刊：
影响因子：
4
通讯作者：
Nijhout, HF
中科院分区：
文献类型：
--
作者：
Nijhout, HF
如果性状的变异与遗传或环境变量的变异弱相关，则该性状对该变量具有鲁棒性。稳健性的来源在于，产生复杂性状的发育过程是非线性的。这种非线性的结果是，并不是所有的基因都与它们所控制的个体发育的性状同样相关。在这里，我们将探讨发育机制如何决定和改变基因和它们控制的性状之间的相关结构。一个公式的开发，通过该基因或环境变量与性状的相关性可以计算，如果机制，引起的性状是已知的。鲁棒性的性质和鲁棒性可以发展的方式进行了讨论的背景下出现的问题，在分析固有的非线性系统。(C)2002 Wiley Periodicals，Inc.
A trait is robust to a genetic or environmental variable if its variation is weakly correlated with variation in that variable. The source of robustness lies in the fact that the developmental processes that give rise to complex traits are nonlinear. A consequence of this nonlinearity is that not all genes are equally correlated with the trait whose ontogeny they control. Here we explore how developmental mechanisms determine and alter the correlation structure between genes and the traits that they control. A formula is developed by which the correlation of a gene or environmental variable with a trait can be calculated if the mechanism that gives rise to the trait is known. The nature of robustness and the ways in which robustness can evolve are discussed in the context of the problems that arise in the analysis of inherently nonlinear systems. (C) 2002 Wiley Periodicals, Inc.