Systemic pigmentation from tetracycline and minocycline therapy.
Systemic pigmentation from tetracycline and minocycline therapy.
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DOI：
10.1001/archderm.1983.01650250005001
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发表时间：
1983
影响因子：
--
通讯作者：
S. White;C. Besanceney
中科院分区：
文献类型：
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作者：
S. White;C. Besanceney
致编辑据报道，盐酸米诺环素是治疗四环素敏感和四环素耐药的寻常痤疮的安全有效的药物。1长期和高剂量给予米诺环素已知会导致下肢皮肤的蓝色或蓝黑色色素沉着过度和萎缩性瘢痕。2当长期给予四环素时，3四环素治疗后可见黄色骨骼。4本报告描述了一名长期接受高剂量盐酸四环素和米诺环素治疗的患者的临床和尸检结果。一个案例的报告- 1978年1月，一名19岁男性首次出现在Keller Army Hospital（西点，NY）皮肤科诊所，患有II-III级痤疮（Pillsbury分类）。患者既往未接受痤疮治疗。给予患者250 mg盐酸四环素，每日4次，外用红霉素洗剂。六周
To the Editor.— Minocycline hydrochloride is reported to be a safe and effective agent in the treatment of tetracycline-sensitive and tetracycline-resistant acne vulgaris.1Long-term and high-dose administration of minocycline is known to cause blue or blue-black hyperpigmentation of the skin on the lower extremities, and atrophic scars.2When tetracyclines are given over prolonged periods, brown-black microscopic discoloration of the thyroid gland is seen.3Yellow bones have been noted following tetracycline therapy.4This report describes clinical and postmortem findings of a patient treated with high-dose, long-term tetracycline hydrochloride and minocycline. Report of a Case.— In January 1978 a 19-year-old man was first seen in the dermatology clinic of Keller Army Hospital, West Point, NY, with grade II-III acne (Pillsbury classification). He had not received prior therapy for acne. He was given 250 mg of tetracycline hydrochloride four times daily and a topical erythromycin base lotion. Six weeks