Stress-induced metastatic niches in breast cancer

Stress-induced metastatic niches in breast cancer
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压力诱导的乳腺癌转移位

DOI:
10.1080/23723556.2020.1780105
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发表时间:
2020
影响因子:
2.1
通讯作者:
Oskarsson T
Oskarsson T
中科院分区:
--
文献类型:
--
作者:
Oskarsson T

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在大多数恶性肿瘤中,播散的癌细胞与次级器官中的微环境之间的相互作用对于转移的发展至关重要。转移起始细胞及其后代可以改变微环境,导致形成转移性小生境,支持继发部位的恶性生长。我们最近的研究结果表明,应激反应通过调节细胞外基质和促进与反应性成纤维细胞的相互作用,在乳腺癌转移性壁龛的产生中起着至关重要的作用。
Interactions between disseminated cancer cells and the microenvironment in secondary organs are essential for the development of metastasis in most malignancies. Metastasis-initiating cells and their progeny can impose changes in the microenvironment leading to the formation of a metastatic niche that supports malignant growth at secondary sites. Our recent findings indicate that stress responses play a crucial role in generation of metastatic niches in breast cancer by modulating the extracellular matrix and promoting interactions with reactive fibroblasts.
DOI: 10.15252/emmm.201809003
发表时间: 2018-10
影响因子: 11.1
作者:
Insua-Rodríguez J;Pein M;Hongu T;Meier J;Descot A;Lowy CM;De Braekeleer E;Sinn HP;Spaich S;Sütterlin M;Schneeweiss A;Oskarsson T
通讯作者: Oskarsson T