Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
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DOI：
10.1128/aac.50.5.1893-1895.2006
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发表时间：
2006-05-01
影响因子：
4.9
通讯作者：
Dorsey, G
中科院分区：
文献类型：
--
作者：
Dokomajilar, C;Nsobya, SL;Dorsey, G
恶性疟原虫pfmdr 1基因的多态性进行了分析，在治疗前的样品和蒿甲醚-苯芴醇治疗后再感染的患者的样品。治疗后pfmdr 1等位基因86 N、184 F和1246 D的患病率显著增加。所有样本都有一个pfmdr 1拷贝。蒿甲醚-苯芴醇治疗选择可能改变抗疟药物反应的多态性。
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.