In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications
In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications
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硫化铜纳米片潜在光热应用的体外和体内毒性研究
DOI：
10.1016/j.nano.2014.12.015
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发表时间：
2015-05-01
影响因子：
5.4
通讯作者：
He, Chuanglong
中科院分区：
文献类型：
--
作者：
Feng, Wei;Nie, Wei;He, Chuanglong
硫化铜（cu）是一种很有前途的光热剂。然而，人们对其潜在的毒性作用仍然知之甚少。本文合成了cu纳米片用于毒性评价。体外实验表明，当cu纳米板浓度高于100 μ g/mL时，细胞活力下降。cu纳米板对HUVEC和RAW 264.7细胞有明显的毒性作用。急性毒性的最大耐受剂量和致死剂量分别为8.66和54.5 mg/ kg。此外，亚慢性毒性试验结果表明，在试验期间，在试验剂量下没有明显的影响。生物分布研究表明，静脉给药的cu纳米片主要存在于脾脏、肝脏和肺部。综上所述，我们的研究结果为合理设计cu纳米材料以减少毒性提供了思路，从而为选择cu作为光热剂用于癌症治疗提供了有益的指导。来自临床编辑：光热消融治疗是一种很有前途的治疗癌症的新方式。硫化铜（cu）是一种潜在的光热剂。本文研究了cu纳米片的潜在毒性作用。作者指出，需要进一步修改cu纳米材料的设计，以尽量减少毒性。(C) 2015爱思唯尔公司版权所有。
Copper sulfide (CuS) has emerged as a promising photothermal agent. However, its potential toxic effects still remained poorly understood. Herein, CuS nanoplates were synthesized for toxicity assessment. The in vitro study indicated that the cell viability decreased when CuS nanoplate concentration was higher than 100 mu g/mL. CuS nanoplates caused apparent toxicity to HUVEC and RAW 264.7 cells. For acute toxicity, maximum tolerated dose and lethal dose 50 were 8.66 and 54.5 mg/ kg, respectively. Furthermore, the sub-chronic toxicity test results indicated that there was no obvious effect at tested doses during the test period. The biodistribution study showed that intravenously administrated CuS nanoplates were mainly present in the spleen, liver and lung. Taken together, our results shed light on the rational design of CuS nanomaterials to minimize toxicity, thus providing a useful guideline in selecting CuS as the photothermal agent for cancer therapy.From the Clinical Editor: Photothermal ablation therapy is a promising new treatment modality for cancer. One of the potential photothermal agents is copper sulfide (CuS). In this article, the potential toxic effects of CuS nanoplates were studied. The authors showed that further modification on the design of CuS nanomaterials was needed to minimize toxicity. (C) 2015 Elsevier Inc. All rights reserved.