Three-Dimensional Printed Patient Specific Ptosis Crutches as a Nonsurgical Solution for Elevating Upper Eyelids in Myasthenia Gravis Patients
Three-Dimensional Printed Patient Specific Ptosis Crutches as a Nonsurgical Solution for Elevating Upper Eyelids in Myasthenia Gravis Patients
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DOI：
10.1115/1.4033225
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发表时间：
2016-06-01
影响因子：
0.9
通讯作者：
Sivarasu, Sudesh
中科院分区：
文献类型：
--
作者：
Findlay, Megan;Heckmann, Jeannine M.;Sivarasu, Sudesh
背景重症肌无力（Myasthenia gravis，MG）是一种影响神经肌肉接头的可治疗的自身免疫性疾病[1，2]。MG的特征在于随意骨骼肌的疲劳性肌无力，其中最常受影响的肌肉是眼和面部肌肉。目前北美数据的估计表明MG的患病率约为200/百万[3]。南非人群的发病率与世界其他地区相似[1]。虽然MG影响所有种族群体的个体，但该疾病的治疗结果因种族而异[4]。与欧洲患者相比，非洲遗传血统的患者，特别是青少年，更有可能发生MG的眼肌并发症[5]。MG眼肌麻痹的并发症包括持续的眼睛移动困难和眼睑下垂，尽管治疗。
BackgroundMyasthenia gravis (MG) is a treatable autoimmune disorder that effects the neuromuscular junction [1, 2]. MG is characterized by fatigable muscle weakness of voluntary skeletal muscles with the most commonly affected muscles being the eye and facial muscles. The current estimates from North American data suggests that the prevalence of MG is around 200 per million [3]. The incidence within the South Africa population is similar to the rest of the world [1]. While MG affects individuals of all racial groups, the outcome to therapy of the disease differs across races [4]. Patients of African genetic ancestry, particularly juveniles, are more likely to develop ocular muscle complications of MG when compared to their European counterparts [5]. MG ophthalmoplegic complications include persistent difficulty in moving the eyes and blepharoptosis, despite treatment.