Freeze-etch electron microscopy of erythrocytes, Acholeplasma laidlawii cells and liposomal membranes after the action of filipin and amphotericin B.
Freeze-etch electron microscopy of erythrocytes, Acholeplasma laidlawii cells and liposomal membranes after the action of filipin and amphotericin B.
复制标题
菲律宾素和两性霉素 B 作用后的红细胞、莱拉氏无胆原体细胞和脂质体膜的冷冻蚀刻电子显微镜观察。
DOI：
10.1016/0005-2736(73)90509-9
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
P. Ververgaert
中科院分区：
文献类型：
--
作者：
A. Verkleij;B. Kruijff;W. Gerritsen;Rudy A. Demel;L. M. Deenen;P. Ververgaert
冷冻蚀刻电子显微镜观察表明，在大鼠红细胞膜、LaidlawiicAcholeplasma细胞含胆固醇膜和卵磷脂胆固醇脂质体中，菲律平诱导形成直径为150- 250 μ m的聚集体。当A膜中不存在胆固醇时，未观察到断裂面的变化。两性霉素B不明显影响红细胞的冷冻蚀刻形态，含胆固醇A。Laidlawiicells和卵磷脂-胆固醇脂质体。
Freeze-etch electron microscopy demonstrated that filipin induces the formation of aggregates 150–250Åin diameter, in the membranes of rat erythrocytes, in cholesterol-containing membranes ofAcholeplasma laidlawiicells and in egg lecithin-cholesterol liposomes. No change in fracture faces was observed when cholesterol was absent in the membranes ofA. laidlawii, and lecithin liposomes.Amphotericin B does not visibly affect the freeze-etch morphology of erythrocytes, cholesterol-containingA. laidlawiicells and lecithin-cholesterol liposomes.