Electro-entropic excluded volume effects on DNA looping and relaxation in nanochannels
Electro-entropic excluded volume effects on DNA looping and relaxation in nanochannels
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DOI：
10.1063/1.4826157
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发表时间：
2013-09-01
期刊：
影响因子：
3.2
通讯作者：
Chen, Yeng-Long
中科院分区：
文献类型：
--
作者：
Chen, Yeng-Long
我们研究了方形纳米通道中熵限制的 DNA 分子的波动弛豫动力学，其范围为持久长度的 0.09 至 19.9 倍。在小于持久长度的纳米通道中，发现链弛豫时间对通道尺寸具有三次依赖性。研究发现，有效聚合物宽度显着改变强约束下的链构象和弛豫时间。对于较细的链，在高度与持久长度相当的通道中发现环状链配置，与非环状链相比，松弛非常缓慢。较大的有效链宽度抑制发夹环的形成。 (C) 2013 年作者。除非另有说明，所有文章内容均根据 Creative Commons Attribution 3.0 Unported License 获得许可。
We investigate the fluctuation-relaxation dynamics of entropically restricted DNA molecules in square nanochannels ranging from 0.09 to 19.9 times the persistence length. In nanochannels smaller than the persistence length, the chain relaxation time is found to have cubic dependence on the channel size. It is found that the effective polymer width significantly alter the chain conformation and relaxation time in strong confinement. For thinner chains, looped chain configurations are found in channels with height comparable to the persistence length, with very slow relaxation compared to un-looped chains. Larger effective chain widths inhibit the formation of hairpin loops. (C) 2013 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.