On the potential for molecular imaging with Cerenkov luminescence.
On the potential for molecular imaging with Cerenkov luminescence.
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DOI：
10.1364/ol.35.003889
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发表时间：
2010-12-01
期刊：
影响因子：
3.6
通讯作者：
Mason RP
中科院分区：
文献类型：
--
作者：
Lewis MA;Kodibagkar VD;Öz OK;Mason RP
最近观察到的光学发光由于β衰变从合适的放射性示踪剂导致了新的临床前光学成像方法的可能发展。可以使用针对生物发光成像优化的仪器检测到的光子的产生已经与切伦科夫效应完全相关。我们描述了同时利用荧光报告转换的切伦科夫发光更长的波长，更好的组织渗透，也为潜在的分子成像策略调制的发光光谱。
Recent observation of optical luminescence due to beta decay from suitable radiotracers has led to the possible development of new preclinical optical imaging methods. The generation of photons that can be detected using instrumentation optimized for bioluminescence imaging has been putatively associated with the Cerenkov effect. We describe the simultaneous utilization of fluorescence reporters to convert the Cerenkov luminescence to longer wavelengths for better tissue penetration and also for modulating the luminescence spectrum for potential molecular imaging strategies.