The pathobiology of glioma tumors.
The pathobiology of glioma tumors.
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DOI：
10.1146/annurev-pathol-121808-102109
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Liu WM
中科院分区：
文献类型：
--
作者：
Gladson CL;Prayson RA;Liu WM
The ongoing characterization of the genetic and epigenetic alterations in the gliomas has already improved the classification of these heterogeneous tumors and enabled the development of rodent models for analysis of the molecular pathways underlying their proliferative and invasive behavior. Effective application of the targeted therapies that are now in development will depend on pathologists’ ability to provide accurate information regarding the genetic alterations and the expression of key receptors and ligands in the tumors. Here we review the mechanisms that have been implicated in the pathogenesis of the gliomas and provide examples of the cooperative nature of the pathways involved, which may influence the initial therapeutic response and the potential for development of resistance.
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