Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey.
复制标题
DOI：
10.1590/abd1806-4841.20164766
复制
发表时间：
2016-09
影响因子：
1.7
通讯作者：
Alptekin D
中科院分区：
文献类型：
--
作者：
Izmirli M;Sen BB;Rifaioglu E;Gogebakan B;Aldemir O;Sen T;Ekiz O;Alptekin D
Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.
登录
查看更多内容
影响因子：
4.2
作者：
Bailey, LB;Gregory, JF
通讯作者：
Gregory, JF
影响因子：
1.7
作者：
Silva, Maria Flavia Pereira da;Fortes, Maria Rita Parise;Marques, Silvio Alencar
通讯作者：
Marques, Silvio Alencar
影响因子：
3.6
作者：
Weger, Wolfgang;Hofer, Angelika;Salmhofer, Wolfgang
通讯作者：
Salmhofer, Wolfgang
DOI：
10.1111/j.1365-2133.2008.08898.x
发表时间：
2009-02
期刊：
The British journal of dermatology
影响因子：
--
作者：
Warren RB;Smith RL;Campalani E;Eyre S;Smith CH;Barker JN;Worthington J;Griffiths CE
通讯作者：
Griffiths CE
影响因子：
6.5
作者：
Fleischer, AB;Feldman, SR;Rajashekhar, V
通讯作者：
Rajashekhar, V