Obesity: Pathophysiology and Management.
Obesity: Pathophysiology and Management.
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DOI：
10.1016/j.jacc.2017.11.011
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发表时间：
2018-01-02
影响因子：
24
通讯作者：
Heymsfield SB
中科院分区：
文献类型：
--
作者：
Gadde KM;Martin CK;Berthoud HR;Heymsfield SB
肥胖症仍然是全球最高的健康问题，尽管我们没有含有肥胖症的高度，但我们现在对其病理生理学有了更好的了解，以及如何超越肥胖建议修改作为肥胖管理的基石，但由于难以依从性以及身体的身体和神经激素适应，许多患者对体重减轻，五种药物疗法 - 洛里斯塔特，洛斯氏菌，洛里斯汀，没有实现持久的益处。 ，liraglutide，苯甲酸/甲前甲酸酯和纳曲酮/bupropion可用于长期体重管理。糖尿病尽管成本高和严重并发症的风险很小，但对于严重的肥胖症患者来说，糖尿病应指导治疗决策。
Obesity continues be among the top health concerns across the globe. Despite our failure to contain the high prevalence of obesity, we now have a better understanding of its pathophysiology, and how excess adiposity leads to type 2 diabetes, hypertension, and cardiovascular disease. Lifestyle modification is recommended as the cornerstone of obesity management, but many patients do not achieve long-lasting benefits due to difficulty with adherence as well as physiological and neurohormonal adaptation of the body in response to weight loss. Fortunately, five drug therapies – orlistat, lorcaserin, liraglutide, phentermine/topiramate, and naltrexone/bupropion are available for long-term weight management. Additionally, several medical devices are available for short-term and long-term use. Bariatric surgery yields substantial and sustained weight loss with resolution of type 2 diabetes, although due to high cost and a small risk of serious complications, it is recommended for patients with severe obesity. Benefit-to-risk balance should guide treatment decisions.
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影响因子：
6.9
作者：
Bergman, Richard N.;Stefanovski, Darko;Buchanan, Thomas A.;Sumner, Anne E.;Reynolds, James C.;Sebring, Nancy G.;Xiang, Anny H.;Watanabe, Richard M.
通讯作者：
Watanabe, Richard M.
影响因子：
6.3
作者：
Dhana, Klodian;Kavousi, Maryam;Franco, Oscar H.
通讯作者：
Franco, Oscar H.
影响因子：
3.6
作者：
Breton, Emily R.;Fuemmeler, Bernard F.;Abroms, Lorien C.
通讯作者：
Abroms, Lorien C.
影响因子：
5.4
作者：
Angulo MA;Butler MG;Cataletto ME
通讯作者：
Cataletto ME
影响因子：
6.9
作者：
Aronne, Louis J.;Wadden, Thomas A.;Gadde, Kishore M.
通讯作者：
Gadde, Kishore M.