Associations of PM2.5 intensity and duration with cognitive function: A longitudinal analysis of middle-aged and older adults in China
Associations of PM2.5 intensity and duration with cognitive function: A longitudinal analysis of middle-aged and older adults in China
复制标题
PM2.5强度和持续时间与认知功能的关联：中国中老年人的纵向分析
DOI：
10.1016/j.envres.2022.114261
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发表时间：
2022
影响因子：
8.3
通讯作者：
Qingqing He
中科院分区：
文献类型：
--
作者：
Kai Hu;Qingqing He
长期暴露于空气污染与认知障碍的风险较高有关;然而，对这种关联的理解是不完整的。我们的目的是探索细颗粒物（PM2.5）暴露与认知功能之间的关系，使用一个前瞻性的老年人队列，包括中国健康与退休纵向研究（CHARLS，2011-2018）的19，389名受访者，这些受访者与中国历史PM2.5浓度（2000-2018）有关。通过将暴露强度（平均PM2.5浓度）的暴露度量扩展到暴露持续时间（高PM2.5浓度的月数），我们采用了两个线性模型，即固定效应和混合效应线性模型，来估计PM2.5暴露与认知表现之间的关联，并对个体和区域协变量进行了调整。我们的研究结果表明，较高的PM2.5强度与较差的认知功能相关，但仅在较长的暴露时间（超过1年），特别是在10年的暴露中，这种相关性才具有统计学意义（系数：-0.13; 95%置信区间：-0.22，-0.04）。在完全调整的PM2.5持续时间模型中也观察到了类似的模式：PM2.5浓度持续时间越长，认知得分越低，除75 μg/m3的持续时间外，具有较高截断点的持续时间对认知功能的影响更大，这表明空气污染增加和经济发展可能是巧合。更强的PM2.5暴露与中国成年人的认知功能较差有关，而需要更多的工作来将空气污染暴露与个人的背景特征分开，特别是那些与认知功能和城市生活共同相关的特征。
Long-term exposure to air pollution is associated with a higher risk of cognitive impairment; however, the understanding of this association is incomplete. We aimed to explore the relationship between fine particulate matter (PM2.5) exposure and cognitive function using a prospective cohort of ageing adults, including 19,389 respondents of the China Health and Retirement Longitudinal Study (CHARLS, 2011-2018) linked with the historical PM2.5 concentrations (2000-2018) in China. By extending the measure of exposure from exposure intensity (averaged PM2.5 concentrations) to exposure duration (the number of months with high PM2.5 concentrations), we employed two linear models, the fixed-effect and mixed-effect linear models, to estimate the associations between PM2.5 exposure and cognitive performance, with adjustments for individual and regional covariates. Our findings shows that the higher PM2.5 intensity was associated with worse cognitive function, but the associations were only statistically significant in a longer exposure period (more than one year), especially in the 10-year exposure (Coefficient: -0.13; 95% Confidence Interval: -0.22, -0.04). Similar patterns were seen for fully adjusted models of PM2.5 duration: a longer duration in PM2.5 concentration was associated with lower cognitive scores, and the duration with higher cut-off points had stronger effects on cognitive function except for the duration at 75 μg/m3, suggesting a possible coincidence of increasing air pollution and economic development. The stronger exposure to PM2.5 was associated with poorer cognitive function among Chinese adults, while more work is necessary to disentangle air pollution exposure from individuals' background characteristics, particularly those jointly associated with cognitive function and urban living.