Detection of recent HIV-1 infections among men who have sex with men in Beijing during 2005-2006
Detection of recent HIV-1 infections among men who have sex with men in Beijing during 2005-2006
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DOI：
10.1097/00029330-200806020-00013
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发表时间：
2008-06-20
影响因子：
6.1
通讯作者：
Shao Yi-Ming
中科院分区：
文献类型：
--
作者：
Li Shen-Wei;Zhang Xiao-Yan;Shao Yi-Ming
研究背景男男性接触者（MSM）已成为我国HIV感染的高危人群之一。虽然已经进行了一些横断面的血清流行病学研究，但该人群的年HIV感染率仍然未知。方法采用BED-CEIA方法对2005年和2006年北京市男男性行为人群HIV-1感染情况进行分析，并对2005年和2006年北京市男男性行为人群HIV-1感染率进行估计。包括2005年的526个样本和2006年的541个样本。2005年，在17例HIV血清阳性样本中，7例被确定为近期HIV-1感染，估计HIV感染率为每年2.9%（95%CI，0.8%-5.0%）。2006年，在26例HIV血清阳性样本中，9例被确定为近期HIV-1感染者，估计年发病率为3.6%（95%CI，1.30%-5.9%），比2005年上升0.7%。参与男性群体性交的个人（5.17%vs0.87%，P=0.019）和接受性肛交5次以上（2.79%对0.33%，P=0.047）显著增加了HIV-1感染的风险。2005年和2006年北京市男男性接触者中1型感染的发病率连续两年呈上升趋势。男男性接触者的发病率和相关的高危行为的上升引起了卫生当局的警觉，并呼吁在这一人群中采取更有效的干预策略。
Background Men who have sex with men (MSM) have become one of the most risky populations for HIV infection in China. Though several cross-sectional sero-prevalence studies have been conducted, the annual HIV incidence remains unknown in this population.Methods We applied IgG-capture BED-enzyme immunoassay (BED-CEIA) to define the recent HIV-1 infections among MSM in Beijing in the years 2005 and 2006 and the annual HIV incidence was estimated.Results Overall, 1067 MSM samples were collected, including 526 samples in the year 2005 and 541 in 2006. In 2005, of 17 HIV seropositive samples, 7 were identified as recent HIV-1 infections and the estimated HIV infection incidence was 2.9% per year (95% CI, 0.8%-5.0%). In 2006, of 26 HIV seropositive samples, 9 were identified as recent HIV-1 infections and the estimated annual incidence was 3.6% (95% CI, 1.30%-5.9%), which was 0.7% higher than that in 2005. Individuals engaging in male group sexual intercourse (5.17% vs 0.87%, P=0.019) and having receptive anal sexual intercourse more than five times (2.79% vs 0.33%, P=0.047) in the past 6 months significantly increase the risk of being infected by HIV-1.Conclusions A high level of annual HIV-1 infection incidence was observed among MSM in Beijing for the consecutive years 2005 and 2006 with a continuous increasing trend. The rising incidence and related high risk behavior among MSM alarmed the health authorities and calls for more effective intervention strategies among this population.