Effect of vasa recta flow on concentrating ability of models of renal inner medulla.
Effect of vasa recta flow on concentrating ability of models of renal inner medulla.
复制标题
直肠血管血流对肾内髓质模型浓缩能力的影响。
DOI：
10.1152/ajprenal.1995.268.4.f698
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Tewarson,RP
中科院分区：
文献类型：
--
作者：
Stephenson,JL;Wang,H;Tewarson,RP
在本研究中，我们扩展了前两项研究的分析[J]。L. Stephenson， J. F. Jen， H. Wang， R. P. Tewarson。点。[j] .中华肾脏病杂志，2006,(5):387 - 398；和任家富，王洪辉，R. P. Tewarson， J. L. Stephenson。点。[j]中华肾外科杂志，2006(2):1 - 7。肾元和直血管长度的分布表现为从降流到升流的分流。研究发现，结构径向分离对富集能力的影响与直血管流动密切相关。在极少或无直血管流动的情况下，径向混合程度对浓缩能力影响不大。随着直血管流量的增加，径向混合降低了浓缩能力。NaCl的对流上坡运输再次被观察到，但浓缩能力似乎主要取决于尿素从收集管输送到髓质内部，而不是盐从细升肢输送的机制。中央核心模型给出了浓缩能力的上界，但没有达到大鼠尿渗透压的最大尿渗透压与小管渗透性的实验值。
In this study we extend the analysis of the preceding two studies [J. L. Stephenson, J. F. Jen, H. Wang, and R. P. Tewarson. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F698–F709, 1995; and J. F. Jen, H. Wang, R. P. Tewarson, and J. L. Stephenson. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F000–F000, 1995] to a model that includes vasa recta. Distribution of nephron and vasa recta lengths is represented by shunting from descending to ascending flow. It is found that the effect of radial separation of structures on concentrating ability is closely linked to vasa recta flow. With minimal or no vasa recta flow the extent of radial mixing has little effect on concentrating ability. As vasa recta flow increases, concentrating ability is decreased by radial mixing. Convective uphill transport of NaCl is again observed, but concentrating ability appears to depend primarily on urea delivery to the inner medulla from the collecting duct rather than on the mechanism of salt transport out of thin ascending limb. Central core models give an upper bound on concentrating ability but do not attain the maximum urine osmolality of the rat with experimental values of tubular permeabilities.