Bacterial microbiome of lungs in COPD.
Bacterial microbiome of lungs in COPD.
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DOI：
10.2147/copd.s38932
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发表时间：
2014
影响因子：
2.8
通讯作者：
Sin DD
中科院分区：
文献类型：
--
作者：
Sze MA;Hogg JC;Sin DD
慢性阻塞性肺疾病（COPD）目前是世界上第三大死亡原因。虽然吸烟是这种疾病的主要危险因素，但只有少数吸烟者会患上COPD。为什么会发生这种情况在很大程度上是未知的。人类微生物组项目的最新发现为人类不同身体部位细菌微生物群的重要性和丰富性提供了新的线索。微生物群在免疫系统的发育和功能完整性中起着特别重要的作用。微生物群的变化或扰动可能导致疾病。COPD部分由对香烟烟雾和其他环境损伤的免疫反应失调介导。尽管传统上肺被视为无菌器官，但通过使用高度敏感的基因组技术，最近的报告已经确定了人肺中可能在COPD中发生变化的多种细菌群落。本文就COPD患者肺部微生物群的变化及其对COPD发病机制的影响作一综述。
Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death in the world. Although smoking is the main risk factor for this disease, only a minority of smokers develop COPD. Why this happens is largely unknown. Recent discoveries by the human microbiome project have shed new light on the importance and richness of the bacterial microbiota at different body sites in human beings. The microbiota plays a particularly important role in the development and functional integrity of the immune system. Shifts or perturbations in the microbiota can lead to disease. COPD is in part mediated by dysregulated immune responses to cigarette smoke and other environmental insults. Although traditionally the lung has been viewed as a sterile organ, by using highly sensitive genomic techniques, recent reports have identified diverse bacterial communities in the human lung that may change in COPD. This review summarizes the current knowledge concerning the lung microbiota in COPD and its potential implications for pathogenesis of the disease.