The Combined Influence of Psychological Factors on Biomarkers of Renal Functioning in African Americans.
The Combined Influence of Psychological Factors on Biomarkers of Renal Functioning in African Americans.
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DOI：
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发表时间：
2015-05
影响因子：
3.2
通讯作者：
Georica Gholson;D. Mwendwa;R. Wright;C. Callender;A. Campbell
中科院分区：
文献类型：
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作者：
Georica Gholson;D. Mwendwa;R. Wright;C. Callender;A. Campbell
目的非裔美国人不成比例地受到慢性肾脏病（CKD）的影响。最近的研究表明，心理因素对CKD的进展和治疗有重要影响。然而，现存的证据已经研究了非裔美国人的心理因素和肾功能之间的联系。该研究的目的是确定心理因素是否与该组中几种肾功能生物标志物相关。参与者129名非裔美国人参与者，平均年龄为44.4岁（SD = 12.25）。设计和设置数据分析来自一个横断面研究，题为压力和心理神经免疫因素在肾脏健康和疾病。主要预测指标：参与者完成贝克抑郁量表-II，库克混合泳量表，和感知压力量表-10。主要观察指标：收集患者的血压、血、尿标本，作为肾功能的生物标志物。结果心理因素与肾功能无相关性。年龄、性别和收缩压是肾功能的重要预测因素。结论：抑郁症，知觉压力和敌意并没有影响肾功能在这个样本。这一意外发现可能归因于这样一个事实，即该样本人群在抑郁症状、感知压力或敌意方面没有升高。这些心理因素以及其他与CKD相关的心理因素的水平升高可能对非裔美国人的肾功能更有影响。
OBJECTIVE African Americans are disproportionately affected by chronic kidney disease (CKD). Recent research has documented that psychological-factors have a significant influence on the progression and treatment of CKD. However, extant evidence exists that has examined the link between psychological factors and renal function in African Americans. The purpose of the study was to determine if psychological factors were associated with several biomarkers of renal functioning in this group. PARTICIPANTS 129 African American participants, with a mean age of 44.4 years (SD = 12.25). DESIGN AND SETTING Data were analyzed from a cross-sectional study entitled Stress and Psychoneuroimmunological Factors in Renal Health and Disease. MAIN PREDICTOR MEASURES: Participants completed the Beck Depression Inventory-II, Cook Medley Scale, and Perceived Stress Scale-10. MAIN OUTCOME MEASURES Systolic blood pressure, as well as blood and urine samples, were collected and served as biomarkers of renal functioning. RESULTS Our findings indicated that psychological factors were not associated with renal functioning. Age, sex, and systolic blood pressure emerged as significant predictors of renal functioning. CONCLUSIONS Depressive symptomatology, perceived stress, and hostility did not influence renal functioning in this sample. This unexpected finding may be attributed to the fact that this sample population was not elevated on depressive symptoms, perceived stress, or hostility. Elevated levels of these psychological factors, as well as other psychological factors associated with the CKD, may be more influential on renal functioning in African Americans.