Cannabinoid receptors and the cytokine network.
Cannabinoid receptors and the cytokine network.
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大麻素受体和细胞因子网络。
DOI：
10.1007/978-1-4615-5347-2_24
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发表时间：
1998
影响因子：
--
通讯作者：
Friedman,H
中科院分区：
文献类型：
--
作者：
Klein,TW;Newton,C;Friedman,H
大麻成分，尤其是 Δ9-四氢大麻酚 (THC)，已被证明可以在体内和体外模式中调节免疫功能1。然而，药物诱导的免疫调节对宿主感染抵抗力的影响尚不确定，只有少数研究报道了动物感染模型与药物治疗的结合。药物诱导的免疫调节的分子机制尚不清楚。在过去的几年里，内源性大麻素系统已被描述为由受体和配体组成2，并且有证据表明免疫系统的细胞表达这些受体3-5。然而，这些受体在药物诱导的免疫调节中的确切作用尚不清楚。
Marijuana components, especially Δ9-tetrahydrocannabinol (THC), have been shown to modulate immune function in bothin vivoandin vitroparadigms1. However, the impact of drug-induced immunomodulation on host resistance to infection is uncertain and only a few studies have been reported coupling animal infection models and drug treatment. The molecular mechanisms of drug-induced immunomodulation are also unknown. An endogenous cannabinoid system has been described over the past few years composed of receptors and ligands2and evidence suggests that cells of the immune system express these receptors3-5. However, the precise role of these receptors in drug-induced immunomodulation is not clear.