Lipid polymorphism and biomembrane function
Lipid polymorphism and biomembrane function
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DOI：
10.1016/s1367-5931(97)80053-1
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发表时间：
1997-12-01
影响因子：
7.8
通讯作者：
de Kruijff, B
中科院分区：
文献类型：
--
作者：
de Kruijff, B
近年来，在膜脂多态性的生物学、物理化学和技术方面取得了一些重大进展。这些包括鉴定大肠杆菌中膜脂质组成的多态性调节，非双层脂质对蛋白质功能的重要性，含有这些脂质的双层的特殊包装特性，以及膜蛋白从三维双层网络（脂质立方相）中结晶出来。这些令人兴奋的进展使我们更接近理解生物膜的脂质双层结构的悖论和膜蛋白结构和功能的分子基础。
In recent years, several major developments have taken place in the biology, physical chemistry and technology of polymorphism of membrane lipids. These include the identification of polymorphic regulation of membrane lipid composition in Escherichia coli, the importance of nonbilayer lipids for protein functioning, the special packing properties of bilayers containing these lipids, and the crystallization of a membrane protein out of three dimensional bilayer networks (lipid cubic phases). These exciting developments bring us closer to understanding the paradox of the lipid bilayer structure of biomembranes and the molecular basis of membrane protein structure and function.