Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy.
Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy.
复制标题
组织工程方法牙本质/牙髓再生治疗的现状与展望
DOI：
10.1155/2016/9204574
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发表时间：
2016
影响因子：
4.3
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Gong T;Heng BC;Lo EC;Zhang C
近年来，生物材料学和组织工程技术的发展极大地促进了再生牙髓学的发展。这导致了牙髓治疗的范式转变，从简单地用生物惰性材料填充根管系统到用功能性替代组织恢复感染的牙髓。目前，细胞移植作为一种科学有效的牙本质牙髓复合体再生方法越来越受到重视。这种涉及组织工程三个关键要素（干细胞、支架和信号分子）相互作用的多学科方法在临床前动物研究中产生了令人印象深刻的有利结果。然而，在其应用于临床环境之前，需要克服许多实际障碍。除了免疫排斥和病原体传播的潜在健康风险外，缺乏完善的用于分离和储存牙源性干细胞的银行系统是等待解决的最紧迫问题，并且支持性支架材料的性质在不同的研究中有所不同，并且仍然不一致。这篇评论批判性地审查了经典的三重奏组织工程学用于目前的再生牙髓，并总结了可能的技术开发的牙本质/牙髓再生。
Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration.