Melanin concentrating hormone modulates oxytocin-mediated marble burying.
Melanin concentrating hormone modulates oxytocin-mediated marble burying.
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DOI：
10.1016/j.neuropharm.2017.09.008
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发表时间：
2018-01
影响因子：
4.7
通讯作者：
Civelli O
中科院分区：
文献类型：
--
作者：
Sanathara NM;Garau C;Alachkar A;Wang L;Wang Z;Nishimori K;Xu X;Civelli O
重复和持续的行为是许多神经精神疾病的共同特征，例如天使综合症、图雷特综合症、强迫症和自闭症谱系障碍。催产素系统与动物模型和人类重复行为的调节有关，但其许多下游靶点仍有待发现。我们报告说，黑色素浓缩激素（MCH）系统是催产素系统调节一种重复行为（大理石埋藏）的目标。首先，我们报告近 60% 的 MCH 神经元表达催产素受体，并利用狂犬病介导的纤维束示踪证明 MCH 神经元接收来自催产素神经元的直接突触前输入。然后我们发现 MCH 受体敲除 (MCHR1KO) 小鼠和 MCH 消融动物表现出增加的大理石埋藏反应，而中央 MCH 输注则降低了这种反应。最后，我们证明了 MCH 系统对催产素介导的大理石埋藏的下游作用，通过表明中央输注 MCH 和催产素单独或一起减少它，同时拮抗 MCH 系统阻止催产素介导的这种行为的减少。我们的研究结果揭示了 MCH 系统作为催产素在调节小鼠大理石埋藏行为中的调节作用的新作用。
Repetitive and perseverative behaviors are common features of a number of neuropsychiatric diseases such as Angelman’s syndrome, Tourette’s syndrome, obsessive-compulsive disorder, and autism spectrum disorders. The oxytocin system has been linked to the regulation of repetitive behavior in both animal models and humans, but many of its downstream targets have still to be found. We report that the melanin-concentrating hormone (MCH) system is a target of the oxytocin system in regulating one repetitive behavior, marble burying. First we report that nearly 60% of MCH neurons express oxytocin receptors, and demonstrate using rabies mediated tract tracing that MCH neurons receive direct pre-synaptic input from oxytocin neurons. Then we show that MCH receptor knockout (MCHR1KO) mice and MCH ablated animals display increased marble burying response while central MCH infusion decreases it. Finally, we demonstrate the downstream role of the MCH system on oxytocin mediated marble burying by showing that central infusions of MCH and oxytocin alone or together reduce it while antagonizing the MCH system blocks oxytocin-mediated reduction of this behavior. Our findings reveal a novel role for the MCH system as a mediator of the role of oxytocin in regulating marble-burying behavior in mice.
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影响因子：
2.4
作者：
Driessen TM;Eisinger BE;Zhao C;Stevenson SA;Saul MC;Gammie SC
通讯作者：
Gammie SC
影响因子：
48
作者：
Buch, T;Heppner, FL;Waisman, A
通讯作者：
Waisman, A
影响因子：
3.7
作者：
Chung S;Verheij MM;Hesseling P;van Vugt RW;Buell M;Belluzzi JD;Geyer MA;Martens GJ;Civelli O
通讯作者：
Civelli O
影响因子：
5.7
作者：
Callaway EM
通讯作者：
Callaway EM
DOI：
10.1124/jpet.108.143362
发表时间：
2009-05-01
影响因子：
3.5
作者：
Gehlert, Donald R.;Rasmussen, Kurt;Witkin, Jeffrey M.
通讯作者：
Witkin, Jeffrey M.