A comparative study of ethanol absorption in the canine jejunum after pretreatment with cyanamide or pyrazole.
A comparative study of ethanol absorption in the canine jejunum after pretreatment with cyanamide or pyrazole.
复制标题
氰胺或吡唑预处理后犬空肠乙醇吸收的比较研究。
DOI：
10.1093/oxfordjournals.alcalc.a045407
复制
发表时间：
1993
影响因子：
2.8
通讯作者：
K. Ameno
中科院分区：
文献类型：
--
作者：
T. Shinohara;I. Ijiri;S. Ameno;C. Fuke;K. Ameno
本报告描述了使用血管供应完整的空肠段，通过高浓度乙醛抑制犬肠道乙醇吸收和减少门静脉血流量。与对照组和吡唑预处理组（PY）相比，氰胺预处理组（CY）的乙醛浓度极高，门静脉血乙醇逐渐增加，吸收乙醇量减少25%，吸收速率常数（Ka）减小85%。这些事实表明，血液中高乙醛浓度的存在导致乙醇吸收的减少和乙醇到达体循环的延迟。与其他两组相比，CY组中观察到的门静脉血流量的快速减少和门静脉中较低的乙醇水平也表明，通过吸收部位到血液的乙醇渗透性的降低是乙醛诱导的重要阻滞因素。
This report describes the retardation of ethanol absorption from the intestinal tract and reduction of portal blood flow by high acetaldehyde concentrations in dogs using a jejunal segment with the vascular supply intact. The cyanamide-pretreatment group (CY), in which an extremely high acetaldehyde concentration developed, in comparison with the control and pyrazole-pretreated (PY) groups, showed a gradual increase of portal blood ethanol, a 25% reduction in the amount of absorbed ethanol, and an 85% smaller absorption rate constant value (Ka). These facts indicate that the presence of a high acetaldehyde concentration in the blood results in a reduction of ethanol absorption and retardation of ethanol reaching the systemic circulation. The rapid reduction of portal blood flow and the lower ethanol level in the portal vein observed in the CY group, in comparison with the other two groups, also indicate that the reduction of ethanol permeability through the absorption site to the blood is an important retarding factor induced by acetaldehyde.