Practice Effects Predict Cognitive Outcome in Amnestic Mild Cognitive Impairment
Practice Effects Predict Cognitive Outcome in Amnestic Mild Cognitive Impairment
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DOI：
10.1097/jgp.0b013e318209dd3a
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发表时间：
2011-11-01
影响因子：
7.2
通讯作者：
McCaffrey, Robert J.
中科院分区：
文献类型：
--
作者：
Duff, Kevin;Lyketsos, Constantine G.;McCaffrey, Robert J.
目的：实践对认知测试的影响已被证明可进一步表征遗忘型轻度认知障碍（aMCI）患者，并可提供有关随时间推移认知变化的预测信息。我们检验了这样一个假设，即练习效果的丧失预示着aMCI的预后更差。设计：纵向观察设计，跟踪参与者1年。设置：以社区为基础的队列。参会人员：三组老年人：1）认知完整（n = 57），2）在1周内具有较大练习效果的aMCI（MCI + PE，n = 25），和3）在1周内具有最小练习效果的aMCI（MCI-PE，n = 26）。测量：神经心理学测试。结果如下：在控制了年龄和基线认知差异后，MCI-PE组在1年后的即时记忆、延迟记忆、语言和整体认知方面的表现明显差于其他组。结论：虽然这些结果需要在更大的样本中重复，但短期实践效果的丧失预示着aMCI患者的预后更差。(Am J Geriatr Psychiatry 2011; 19：932-939）
Objective: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. Design: Longitudinal, observational design following participants across 1 year. Setting: Community-based cohort. Participants: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26). Measurements: Neuropsychological tests. Results: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. Conclusions: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI. (Am J Geriatr Psychiatry 2011; 19:932-939)