Microbubbles and ultrasound: from diagnosis to therapy.
Microbubbles and ultrasound: from diagnosis to therapy.
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DOI：
10.1016/j.euje.2004.02.001
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发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Kamp, O
中科院分区：
文献类型：
--
作者：
Dijkmans, P A;Juffermans, L J M;Kamp, O
超声造影剂的发展，包含封装微泡，增加了诊断成像的可能性。超声造影剂目前用于增强左心室混浊，增加多普勒信号强度，以及心肌灌注成像。造影剂的诊断成像是在低声压下利用微泡对超声波的非线性反射进行的。超声波会破坏气泡，降低空化阈值，导致微流，增加细胞膜的通透性。有趣的是，这种机制可以用于将药物或基因输送到组织中。微泡已被证明能够携带药物和基因，破坏微泡将导致其内容物在局部释放。最近的研究证明了微泡和超声在溶栓中的潜力。在本文中，我们将回顾微泡作为药物和基因传递载体的最新进展，并讨论微泡在溶栓治疗中的可能应用。
The development of ultrasound contrast agents, containing encapsulated microbubbles, has increased the possibilities for diagnostic imaging. Ultrasound contrast agents are currently used to enhance left ventricular opacification, increase Doppler signal intensity, and in myocardial perfusion imaging. Diagnostic imaging with contrast agents is performed with low acoustic pressure using non-linear reflection of ultrasound waves by microbubbles. Ultrasound causes bubble destruction, which lowers the threshold for cavitation, resulting in microstreaming and increased permeability of cell membranes. Interestingly, this mechanism can be used for delivery of drugs or genes into tissue. Microbubbles have been shown to be capable of carrying drugs and genes, and destruction of the bubbles will result in local release of their contents. Recent studies demonstrated the potential of microbubbles and ultrasound in thrombolysis. In this article, we will review the recent advances of microbubbles as a vehicle for delivery of drugs and genes, and discuss possible therapeutic applications in thrombolysis.