Serum cholesterol and colon cancer incidence in Hawaiian Japanese men.
Serum cholesterol and colon cancer incidence in Hawaiian Japanese men.
复制标题
夏威夷日本男性的血清胆固醇和结肠癌发病率。
DOI：
--
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
A. Kagan
中科院分区：
文献类型：
--
作者：
G. Stemmermann;A. Nomura;L. Heilbrun;E. Pollack;A. Kagan
一项针对8,006名年龄在45-68岁的夏威夷日本男性的癌症和冠心病（CHD）的前瞻性研究表明，血清胆固醇水平低于180 mg/dl预示着冠心病的低发病率和结肠癌的高发病率。结肠癌患者的平均血清胆固醇水平低于其他人群，包括其他部位的癌症患者。血清胆固醇水平最低的是那些死于结肠癌的人。在检查后5-9.9年诊断为结肠癌的患者中，与其他癌症缺乏这种相关性，且这种负相关性持续存在，这表明低血清胆固醇不是由于先前存在的疾病。右结肠肿瘤与血清胆固醇呈最强负相关。冠心病和结肠癌在血清胆固醇方面的差异表明，日本西化人群的不同亚群受到影响。
A prospective study of cancer and coronary heart disease (CHD) in 8,006 Hawaiian Japanese men, aged 45-68 years, showed that serum cholesterol levels below 180 mg/dl predicted low rates of CHD and high rates of colon cancer. Men with colon cancer had lower mean serum cholesterol levels than did other members of the cohort, including those with cancer at other sites. The lowest serum cholesterol levels were obtained from men who died as a result of colon cancer. The lack of such an association with other cancers and the persistence of this inverse association in colon cancer patients diagnosed 5-9.9 years after examination suggest that the low serum cholesterol was not due to preexisting disease. Right colon tumors showed the strongest inverse association with serum cholesterol. The differences between CHD and colon cancer in respect to serum cholesterol indicate that different subsets of the westernized Japanese population are affected.