Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.
Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.
复制标题
DOI：
10.1371/journal.pone.0051548
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Ma Y;Wen X;Peng J;Lu Y;Guo Z;Lu J
更新和完善关于感染性疾病患者门诊他汀类药物使用与死亡率相关性的系统性文献综述。我们通过电子数据库检索了2012年9月31日之前发表的关于他汀类药物与感染性疾病相关死亡率相关性的文章。在Review Manager 5.1中分析了合格文章。我们根据研究设计、感染类型、临床结局和研究地点进行分层分析。41项纳入研究中死亡的合并比值比（OR）（使用他汀类药物vs.未使用）为0. 71（95%置信区间：0. 64，0. 78）。相应的合并OR为0.58（0.38，0.90），0.66（0.57，0.75），0.71（0.57，0.89）和0.83病例对照研究、回顾性队列研究、前瞻性队列研究和随机对照试验的平均可信度分别为（0.67，1.04）; 0.40（0.20，0.78），0.61（0.41，0.90），0.69（0.62，0.78）和0.86（0.68，1.09）用于菌血症、脓毒症、肺炎等感染; 30天、90天、住院和长期（>1年）死亡率分别为0.62（0.534，0.72）、0.68（0.53，0.89）、0.71（0.61，0.83）和0.86（0.70，1.07）。在观察性研究中，门诊使用他汀类药物与感染性疾病患者死亡风险降低相关，但在临床试验中程度较低。这种关联也因感染类型和临床结果而有很大差异。
To update and refine systematic literature review on the association between outpatient statins use and mortality in patients with infectious disease. We searched articles published before September 31, 2012, on the association between statins and infectious disease-related mortality through electronic databases. Eligible articles were analyzed in Review Manager 5.1. We conducted stratification analysis by study design, infection types, clinical outcomes and study locations. The pooled odds ratio (OR) for death (statins use vs. no use) across the 41 included studies was 0.71 (95% confidence interval: 0.64, 0.78). The corresponding pooled ORs were 0.58 (0.38, 0.90), 0.66 (0.57, 0.75), 0.71 (0.57, 0.89) and 0.83 (0.67, 1.04) for the case-control study, retrospective cohort studies, prospective cohort studies and RCTs; 0.40 (0.20, 0.78), 0.61 (0.41, 0.90), 0.69 (0.62, 0.78) and 0.86 (0.68, 1.09) for bacteremia, sepsis, pneumonia and other infections; 0.62 (0.534, 0.72), 0.68 (0.53, 0.89), 0.71 (0.61, 0.83) and 0.86 (0.70, 1.07) for 30-day, 90-day, in-hospital and long-term (>1 year) mortality, respectively. Outpatient statins use is associated with a lower risk of death in patients with infectious disease in observational studies, but in a less extent in clinical trials. This association also varies considerably by infection types and clinical outcomes.
登录
查看更多内容
影响因子：
3.7
作者：
Brett SJ;Myles P;Lim WS;Enstone JE;Bannister B;Semple MG;Read RC;Taylor BL;McMenamin J;Nicholson KG;Nguyen-Van-Tam JS;Openshaw PJ;Influenza Clinical Information Network (FLU-CIN)
通讯作者：
Influenza Clinical Information Network (FLU-CIN)
影响因子：
4.4
作者：
Donnino, Michael W.;Cocchi, Michael N.;Shapiro, Nathan I.
通讯作者：
Shapiro, Nathan I.
影响因子：
9.6
作者：
Frost, Floyd J.;Petersen, Hans;Skipper, Betty
通讯作者：
Skipper, Betty
影响因子：
5.9
作者：
Chalmers, James D.;Singanayagam, Aran;Hill, Adam T.
通讯作者：
Hill, Adam T.
影响因子：
4.1
作者：
Dobesh, Pan P.;Klepser, Donald G.;Olsen, Keith M.
通讯作者：
Olsen, Keith M.