RAT DILATED CARDIOMYOPATHY AFTER AUTOIMMUNE GIANT-CELL MYOCARDITIS
RAT DILATED CARDIOMYOPATHY AFTER AUTOIMMUNE GIANT-CELL MYOCARDITIS
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DOI：
10.1161/01.res.75.2.278
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发表时间：
1994-08-01
影响因子：
20.1
通讯作者：
SHIBATA, A
中科院分区：
文献类型：
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作者：
KODAMA, M;HANAWA, H;SHIBATA, A
扩张型心肌病的可能原因之一被认为是心肌炎的后遗症。在心肌炎进展为扩张型心肌病的过程中，有两种机制被提出：一种是持续的病毒感染，另一种是自身免疫性心肌损伤。为了阐明自身免疫机制在此过程中可能发挥的作用，我们使用动物模型研究了自身免疫性心肌炎（完全与病毒感染无关）是否可能发展为扩张型心肌病。用心肌肌球蛋白组分免疫刘易斯大鼠，诱发实验性自身免疫性心肌炎。对照组用卵白蛋白免疫。临床病程观察4个月以上。肌球蛋白免疫组6只大鼠在急性期和愈合期死亡，所有这些大鼠都有严重的心肌炎。所有存活到研究结束的大鼠都表现出心脏扩大和变色。在开胸手术中观察到右心室动脉瘤样改变。肌球蛋白免疫组的心脏重量与体重的比值显著高于对照组（分别为3.36 ± 0.49和2.69 ± 0.06 g/kg; P
One of the possible causes of dilated cardiomyopathy is considered to be a sequel to myocarditis. Two mechanisms have been proposed in the process of progression of myocarditis into dilated cardiomyopathy: one is a persistent viral infection, and the other is an autoimmune myocardial injury. To clarify the possible part played by the autoimmune mechanism in the process, using an animal model, we investigated whether autoimmune myocarditis, exclusively not related to viral infection, might develop into dilated cardiomyopathy. Experimental autoimmune myocarditis was elicited in Lewis rats by immunization with cardiac myosin fraction. Rats of the control group were immunized with ovalbumin. The clinical course was observed over 4 months. Six rats from the myosin-immunized group died during the acute phase and the healing phase, and all those rats had severe myocarditis. All rats that survived until the end of the study showed enlarged and discolored hearts. Aneurysmal changes were observed in the right ventricle during thoracotomy. The ratio of heart weight to body weight of the myosin-immunized group was significantly higher than that of the control group (3.36+/-0.49 versus 2.69+/-0.06 g/kg, respectively; P