Dendritic cell control of tolerogenic responses.
Dendritic cell control of tolerogenic responses.
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DOI：
10.1111/j.1600-065x.2011.01015.x
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发表时间：
2011-05
影响因子：
8.7
通讯作者：
Pulendran B
中科院分区：
文献类型：
--
作者：
Manicassamy S;Pulendran B
免疫学中最基本的问题之一是免疫系统看似具有精神分裂般的能力：一方面针对病原体发起强大的免疫反应，另一方面对机体自身组织以及每天面对的数以万亿计的共生微生物和食物抗原获得并维持耐受状态。先天免疫系统，特别是树突状细胞（DCs）在协调免疫耐受方面的基本作用已得到认可，但新出现的研究强调了先天受体的性质以及使DCs编程为耐受状态的信号通路。此外，一些研究强调了细胞相互作用以及微环境在编程耐受型DCs中所起的主要作用。在此我们回顾这些研究，并提出对耐受反应的先天控制可被视为不同的组织层次，其中DCs、它们的先天受体和信号网络，以及它们与其他细胞和局部微环境的相互作用代表了该层次的不同水平。
One of the most fundamental problems in immunology is the seemingly schizophrenic ability of the immune system to launch robust immunity against pathogens, while acquiring and maintaining a state of tolerance to the body’s own tissues and the trillions of commensal microorganisms and food antigens that confront it every day. A fundamental role for the innate immune system, particularly dendritic cells (DCs), in orchestrating immunological tolerance has been appreciated, but emerging studies have highlighted the nature of the innate receptors and the signaling pathways that program DCs to a tolerogenic state. Furthermore, several studies have emphasized the major role played by cellular interactions, and the microenvironment in programming tolerogenic DCs. Here we review these studies and suggest that the innate control of tolerogenic responses can be viewed as different hierarchies of organization, in which DCs, their innate receptors and signaling networks, and their interactions with other cells and local microenvironments represent different levels of the hierarchy.